Accurate recognition of anal basaloid squamous cell carcinomas problematically called cloacogentic or transitional in the past , especially their distinction from poorly differentiated adenocarcinoma, urothelial carcinoma and neuroendocrine oat cell carcinoma can be difficult. Tumors with this histology can arise in the high anal transition zone ATZ , which can be difficult to anatomically distinguish from the low-rectum. Therefore, confirmation of this diagnosis requires careful clinical-anatomic correlation in support of ATZ origin. Mucosal architecture is effaced by a nested, nonkeratinizing, non-gland forming basaloid proliferation without obvious squamous or neuroendocrine differentiation. Scant benign surface glandular epithelium is present without detectable mature surface squamous epithelium.
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Anal Carcinoma. Information about Anal cancer. Patient | Patient
A cancer diagnosis can bring a lot of questions and concerns. One of your biggest worries may be about the future. Will you have enough time with your family and other loved ones? Squamous cell carcinoma SCC generally has a high survival rate. The 5-year survival is 99 percent when detected early.
The institution of proper therapy for squamous cell carcinoma of the anus requires an intimate knowledge of the histology and anatomy of this region. It also requires an awareness of the disease entity by the physician and a realization that everything that bleeds around the anus is not due to hemorrhoidal disease. Once the diagnosis and extent of the disease are established, several known facts can be applied in the decision for specific therapy. For small lesions less than 3 cm in diameter located in the perianal skin, it is now clear that wide local excision, usually with skin graft, is a safe, reliable method of treatment.
Anal cancer is cancer that starts in the anus. The anus is the opening at the end of your rectum. The rectum is the last part of your large intestine where solid waste from food stool is stored. Stool leaves your body through the anus when you have a bowel movement. The cause of anal cancer is unclear.